Premarin (Conjugated estrogens)

What is Premarin?

Premarin (Conjugated estrogens) is a blend of estrogen-related compounds, such as equilin, estrone, 17 alpha-dihydroequilin and many others. This generic drug is drawn from the urine of pregnant horses and the precise makeup of the estrogen blend is vague.


Premarin Facts

This generic drug is actually a vaginal cream that is prescribed for curing the painful vaginal symptoms experienced by many women after menopause. Oral as well as vaginal estrogens actually invalidate postmenopausal degeneration of the vaginal inside layer, coagulation of the lining as well as enhancing its secretions. Women already taking estrogen orally do not require using Premarin (Conjugated estrogens). Some of the other uses of this generic drug include avoiding osteoporosis in postmenopausal women as well as reinstating estrogen in women suffering from ovarian failure or other conditions that may result in deficiency of natural estrogen in the body.

Premarin Indications

Premarin (Conjugated estrogens) is used to alleviate vaginal symptoms in postmenopausal women who may be enduring painful dryness of the vagina and/ or vulvae. The generic drug is also used to cure hot flashes, burning sensation and irritation in postmenopausal women. Often, this generic drug is also used as an element of cancer treatment in women as well as men. However, this generic drug should never be used to treat heart ailments or dementia as Permarin (Conjugated estrogens) may actually enhance the risk of developing these conditions.

Premarin Dosage

Like any other vaginal products, Premarin (Conjugated estrogens) also works best during bedtime. This generic drug is available in 42.5 mg tubes and one application includes 0.625 mg using an accompanying applicator. Wash your hands as well as the applicator filled with lotion from the tube carefully before topically applying this generic drug. Patients need to recline on their back with bend knees to insert the applicator into the vagina and push the applicators plunger to deliver this prescription drug. Both, the hands and the applicator should be washed with warm water after use. A little quantity of this generic drug may also be administered on the outer skin fold (lips) of the vagina to alleviate aridity and/ or irritation.

Premarin Side Effects

Like any other generic drug, use of Premain (Conjugated estrogens) also has some side effects. The most common aftereffects of applying this generic drug include blood clots, loss of or extremely prolonged periods, breast enlargement and/ or pain, increase or decrease in libido. In addition, estrogens contained in this generic drug may result in gallstones and this may necessitate surgery. Usage of this prescription drug may also lead to edema (retention of water), melasma (tan or brown patches) on the face. Premarin (Conjugated estrogens) may also enhance the curvature of cornea resulting in discomfort for contact lens users. Although blood clots owing to the use of this prescription drug is rare, women who smoke cigarette are at a greater risk and, hence, should quit smoking while using Premarin (Conjugated estrogens). This drug is absorbed well from the vagina and into the blood. The amount of the prescription drug absorbed depends on the frequency of use and the amount used. Thus, more frequent use or larger amounts of vaginal estrogens may cause side effects all through the body.

Premarin Precautions

Patients enduring conditions such as a history of heart attack, stroke, or blood clot (especially in the lung or lower body), liver disease, abnormal vaginal bleeding, or a hormone-related cancer such as breast or uterine cancer should not use Premarin (Conjugated estrogen). Use of this generic drug may result in birth defects in an unborn baby and so do not use Premarin (Conjugated estrogens) if you are pregnant. Nursing mothers should also not use this drug. At the same time, prolongs use of this drug may augment the risk of breast cancer, heart attack, or stroke. Women using this generic drug should undertake regular physical tests and self-examine their breasts for lumps on a monthly basis. Before you buy Premarin (Conjugated estrogens) or intend to use the drug, discuss with your physicians regarding the risks associated with it.

Premarin Interactions

This generic drug may slow down the elimination of cyclosporine from the body causing enhanced levels of it in the blood and this may result in kidney and/ or liver damage. Women who are above the age of 35 years and those who already have liver ailments are especially at greater risk. Women taking this drug should avoid taking rifampin, carbamazpine, barbiturates, phenytoin, griseofulvin and primidone as all these are able to enhance the elimination of estrogen by augmenting the aptitude of the liver to assimilate it and also diminish the effects of this generic drug.