Pruflox (Prulifloxacin)

What is Pruflox?

Pruflox belongs to a new class of drugs called fluoroquinolones that are effective against both Gram-negative and Gram-positive organisms. That’s why doctors prescribe it to treat such health conditions as acute exacerbations of chronic bronchitis, uncomplicated and complicated lower urinary tract infections. Basically, it’s a prodrug of Ulifloxacin that works by inhibiting the replication of bacteria DNA.


Recommendations for Use

This medication should be taken by patients orally with and without food. After its oral administration, Pruflox is quickly metabolized as the active form of medication, Ulifloxacin. It effectively penetrates the targeted tissues and has a prolonged elimination half-life, so that patients can take it only once a day. Its effect is achieved in 1 hour after its administration, and almost 50% of it is bound to plasma proteins. Another important detail is that Pruflox is extensively metabolized into active metabolites, and it’s excreted mainly through urine.

Besides, patients need to be aware of their right doses, and everything depends on a set of important factors, such as their individual response, characteristics and medical conditions. When it comes to uncomplicated lower urinary tract infections, it’s necessary to take 600 mg on a daily basis to treat its acute cases, including simple cystitis. If people need to treat acute exacerbations of chronic bronchitis, they should take 600 mg for 10 days. The same dosage is recommended to treat complicated lower urinary tract infections.

Precautions and Contraindications

Pruflox is not advisable for those patients who have a range of medical conditions, including fluoroquinolone allergies, tendon-related ailments, uncomplicated skeletal development, G-6-PD, certain infections, improper blood salt levels, celiac disease, seizures, epilepsy and renal impairment. This kind of treatment is not suitable for the elderly because such users are exposed to increased risk of having tendon damages. Besides, all users need to avoid direct exposure to UV rays or sunlight because of their increased sensitivity. Pruflox shouldn’t be taken for longer than needed or prescribed because it may lead to development of bacteria resistant to its use. For pregnant women, it’s allowed to start this kind of treatment only after consulting a doctor. In terms of possible lactation, there are no solid facts about passing the active component of this medicine into the breast milk, but nursing women should be careful, and Pruflox is not recommended for pediatric patients in general.

Drug Interactions

This medication may potentially interact with such drugs as probenecid, NSAIDs, cimetidine, warfarin, theophylline, magnesium and aluminum antacids, quinolones, iron supplements and some others. That’s why patients need to make a list of their medications to show it to their physicians and avoid risky drug interactions and serious symptoms.

Side Effects

There are certain adverse effects that may be resulted by the intake of Pruflox, but the good news is that they happen in rare cases, and they are mild and moderate. For instance, a few patients may end up with drowsiness, itching, confusion, abdominal pain, gastritis, diarrhea, taste changes, hot flashes, losing their appetite, sedation, nausea, vomiting, sleeping difficulty, rash and others. They need to inform their doctors if these symptoms persist or worsen to adjust their treatment accordingly and avoid any health risks.