Sinemet (Carbidopa-Levodopa)

What is Sinemet?

Sinemet is an innovative and highly effective treatment, which contains Levodopa and Carbidopa as active ingredients. The combination of powerful components allows the remedy to eliminate the signs of Parkinson’s disease, especially tremors, poor muscle control, spasms, muscle stiffness and others. Since the signs of Parkinson’s disease can be activated by decreased levels of dopamine in the brain, Sinemet is converted into this chemical within the brain. Additionally, the treatment is aimed at treatment of Parkinson’s disease, provoked by manganese intoxication or carbon monoxide poisoning. Besides, Sinemet can be administered in other instances, not specified in the safety leaflet. Make sure your off-label drug intake is approved by a medical specialist.


Recommendations for Use

The medication promotes a drastic impact on the brain functioning and other essential body organs, so you need to be ultimately cautious using the treatment. Start the course with doctor’s consultation. Stop Levodopa intake minimum for 12 hours before Sinemet intake.

Follow doctor’s recommendations and instructions during the course. Never increase or decrease the dose, duration of the therapy or other intake specifications. Each patient will receive a different dose, but directions for Sinemet use will remain universal for everyone. The drug can be administered with or without food. It is essential to use the treatment regularly, preferably at around the same time daily. Never break, chew or crush the tablet before swallowing. Keep in mind that Sinemet therapy can take several weeks, so keep using the remedy even if the symptoms do not improve. However, contact your doctor in case the condition does not get any better after multiple weeks. Regular blood tests may be required for patients, who take Sinemet long-term. Sudden stop of the therapy can result in severe withdrawal reactions and devastating side effects.

Precautions and Contraindications

Do not start the medication intake if you have any contraindications or restrictions mentioned in the safety leaflet. Patients who are allergic to any ingredient of the drug should avoid its use. Besides, people with narrow-angle glaucoma are not approved for the therapy. MAO inhibitors can boost the effectiveness of Sinemet, leading to overdose with its negative consequences.

Striving to benefit from the treatment course and avoid complications, you need to inform your healthcare specialist about all the accompanying and underlying health disorders you have, especially open-angle glaucoma, kidney or liver disorders, advanced blood pressure, intestinal or stomach ulcers, endocrine disorders, etc.

Drug Interactions

To ensure a fully safe and flawless treatment course, a patient should eliminate the risk of possible Sinemet interaction with other medications. The treatment of Parkinson’s disease can interfere with certain prescription and non-prescription drugs, herbal supplements and vitamins. Therefore, your doctor should be aware of all the therapies you are currently undergoing. Exceptional dose adjustment may be required for patients, who are using some remedies.

Side Effects

Seek immediate medical assistance the moment you have noticed any complications or symptoms aggravation after the drug intake. Pay ultimate attention to allergic reactions, confusion, uncontrolled muscle movements, severe diarrhea, ongoing vomiting, severe reactions of the central nervous system, suicidal thoughts, depression, hallucinations, etc. Besides, warn the medical specialist about minor to moderate health complications such as nausea, muscle contractions, twisting or jerky muscle movements and others.